KHASIAT KARDIOPROTEKTIF VIRGIN COCONUT OIL (VCO) PADA TIKUS YANG TERPAPAR ASAP ROKOK
CARDIOPROTECTIVE PROPERTIES OF VIRGIN COCONUT OIL IN RATS EXPOSED TO CIGARETTE SMOKE
Abstract
Para peneliti telah menghubungkan antioksidan dalam minyak kelapa murni (VCO) dengan peningkatan kesehatan; meskipun demikian, kemampuan kardioprotektif dan antioksidan VCO terhadap stres oksidatif yang disebabkan oleh kebiasaan merokok masih belum banyak dieksplorasi. Penelitian ini meneliti mengenai efek kardioprotektif dan antioksidan VCO dalam kaitannya dengan kerusakan jaringan jantung. Tikus Wistar jantan yang berjumlah 24 ekor dibagi menjadi empat kelompok: Kelompok 1 (kelompok kontrol) menerima pelet tikus; Kelompok 2 (kelompok kontrol positif) diberi diet dasar dan dipapar asap rokok; Kelompok 3 diberi asap rokok bersama dengan 0,45 ml VCO; Kelompok 4 diberi asap rokok ditambah 0,9 ml VCO. Analisis histologis jaringan jantung dilakukan setelah 28 hari pengobatan. Kelompok 2 menunjukkan tingkat kariolisis yang paling menonjol. Secara bersamaan, hasil dari kelompok pengobatan 3, menunjukkan sedikit kerusakan pada miosit jantung. Studi ini menunjukkan bahwa menghirup asap rokok dapat membahayakan jantung dan menegaskan efek kardioprotektif VCO terhadap kerusakan miokardium akibat asap rokok melalui pengurangan stres oksidatif.
References
Perokok Dewasa di Indonesia Meningkat Dalam Sepuluh Tahun Terakhir.
WHO. Tobacco.
Objectives G. GATS | Global Adult Tobacco Survey Indonesia 2021. Published online 2021.
What’s In a Cigarette. Am Lung Assoc. Published online 2021.
Barua RS, Rigotti NA, Benowitz NL, et al. 2018 ACC Expert Consensus Decision Pathway on Tobacco Cessation Treatment: A Report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2022;72(25):3332-3365. doi:10.1016/J.JACC.2018.10.027
Kondo T, Nakano Y, Adachi S, Murohara T. Effects of tobacco smoking on cardiovascular disease. Circ J. 2019;83(10):1980-1985. doi:10.1253/circj.CJ-19-0323
Carnevale R, Sciaretta S, Violi F, et al. Acute Impact of Tobacco vs Electronic Cigarette Smoking on Oxidative Stress and Vascular Function. Chest J. 2016;150(3).
Shechter M, Shechter A, Koren-Morag N, Feinberg MS, Hiersch L. Usefulness of brachial artery flow-mediated dilation to predict long-term cardiovascular events in subjects without heart disease. Am J Cardiol. 2014;113(1):162-167. doi:10.1016/J.AMJCARD.2013.08.051
Ladich E, Yahagi K, Romero ME, Virmani R. Vascular diseases: aortitis, aortic aneurysms, and vascular calcification. Cardiovasc Pathol. 2016;25(5):432-441. doi:10.1016/J.CARPATH.2016.07.002
Famurewa AC, Ugwu-Ejezie CS, Iyare EE, Folawiyo AM, Maduagwuna EK, Ejezie FE. Hepatoprotective effect of polyphenols isolated from virgin coconut oil against sub-chronic cadmium hepatotoxicity in rats is associated with improvement in antioxidant defense system. Drug Chem Toxicol. 2021;44(4):418-426. doi:10.1080/01480545.2019.1598428
Dumancas GG, Kasi Viswanath LC, de Leon AR, et al. Health Benefits of Virgin Coconut Oil.; 2016.
Rahmawatia ED, Khaerunnisya N. Pembuatan VCO ( Virgin Coconut Oil ) dengan Proses Fermentasi dan Enzimatis. J Food Culin. 2018;1(1):1-6.
Illam SP, Narayanankutty A, Raghavamenon AC. Polyphenols of virgin coconut oil prevent pro-oxidant mediated cell death. Toxicol Mech Methods. 2017;27(6):442-450. doi:10.1080/15376516.2017.1320458
Akinnuga AM, Jeje SO, Bamidele O, Sunday VE. Dietary Consumption of Virgin Coconut Oil Ameliorates Lipid Profiles in Diabetic Rats. Physiol J. 2014;2014:1-5. doi:10.1155/2014/256236
Sirait RC, Tjahjono K, Setyawati AN. PENGARUH PEMBERIAN EKSTRAK JINTAN HITAM (Nigella sativa) TERHADAP KADAR MDA SERUM TIKUS SPRAGUE DAWLEY SETELAH DIBERIKAN PAPARAN ASAP ROKOK. DIPONEGORO Med J (Jurnal Kedokt Diponegoro). 2016;5(4):1603-1612. doi:10.14710/DMJ.V5I4.15824
David D, Lambertuis M, Parwanto E, Amalia H. Pengaruh asap rokok terhadap biometrik sel pada sistem respirasi tikus Sprague-Dawley. 2020;(260).
Haqiqoh H, Makiyah SNN. Pengaruh Pemberian VCO (Virgin Coconut Oil) terhadap Gambaran Histologi Tiroid Tikus Putih (Rattus norvegicus). J Kedokt dan Kesehat Mutara Med. 2008;8:30-39.
Dharmawan T. Uji Toksisitas Akut Monocrotophos Dosis Bertingkat per Oral Dilihat Dari Gambaran Histopatologis Otot Jantung Mencit Balb/C. Diponegoro; 2010.
Leone A. Toxics of Tobacco Smoke and Cardiovascular System: From Functional to Cellular Damage. Curr Pharm Des. 2015;21(30):4370-4379. doi:10.2174/1381612821666150803145149
Münzel T, Hahad O, Kuntic M, Keaney JF, Deanfield JE, Daiber A. Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes. Eur Heart J. 2020;41(41):4057-4070. doi:10.1093/eurheartj/ehaa460
Khan NA, Lawyer G, McDonough S, et al. Systemic biomarkers of inflammation, oxidative stress and tissue injury and repair among waterpipe, cigarette and dual tobacco smokers. Tob Control. 2020;29(Suppl 2):s102-s109. doi:10.1136/TOBACCOCONTROL-2019-054958
Daiber A, Steven S, Weber A, et al. Targeting vascular (endothelial) dysfunction. Br J Pharmacol. 2017;174(12):1591-1619. doi:10.1111/bph.13517
Irawan J, Hakim A, Hadisaputra S, Magister ]. Free radical scavenging actions of virgin coconut oil. Acta Chim Asiana. 2022;5(2):202-207. doi:10.29303/ACA.V5I2.120
Nair SS, Manalil JJ, Ramavarma SK, Suseela IM, Thekkepatt A, Raghavamenon AC. Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice. Hum Exp Toxicol. 2016;35(2):205-212. doi:10.1177/0960327115578867
Otuechere CA, Madarikan G, Simisola T, Bankole O, Osho A. Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole. J Basic Clin Physiol Pharmacol. 2014;25(2):249-253. doi:10.1515/jbcpp-2013-0059
Sukirman Lie, Nyoman Ehrich Lister I, Edy Fachrial, Jenny. Cardioprotective effect of virgin coconut oil (VCO) on rats induced by doxorubicin. J Invent Biomed Pharm Sci. 2019;4(3):1-5. doi:10.26452/jibps.v4i3.1430
Subermaniam K, Saad QHM, Kamisah Y, Othman F. Effects of Virgin Coconut Oil on the Histomorphometric Parameters in the Aortae and Hearts of Rats Fed with Repeatedly Heated Palm Oil. Int J Biosci Biochem Bioinforma. 2015;5(2):120-131. doi:10.17706/ijbbb.2015.5.2.120-131
Famurewa AC, Ejezie FE. Polyphenols isolated from virgin coconut oil attenuate cadmium-induced dyslipidemia and oxidative stress due to their antioxidant properties and potential benefits on cardiovascular risk ratios in rats. Avicenna J phytomedicine. 2018;8(1):73-84.
Mutiarahmi CN, Hartady T, Lesmana R. Use of Mice As Experimental Animals in Laboratories That Refer To the Principles of Animal Welfare: a Literature Review. Indones Med Veterinus. 2021;10(1):134-145. doi:10.19087/imv.2020.10.1.134
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